Erasmus Alvey Darwin has rheumatism; his sisters complain of his bad temper but CD thinks him very good tempered. CD has received a new cabinet. [This is the first of six entries written in a "Memorandum book" comprising four sheets folded into a gather and sewn together in book form. The entries are in the style of letters addressed to an unnamed friend and are dated between 1 and 12 January 1822, shortly before CD's thirteenth birthday. As they were written straight into the memorandum book, it is clear that they were never sent through the post, but were either to an imaginary recipient, or intended to be read by someone in the household, possibly CD's youngest sister, Emily Catherine Darwin (Catherine).]

Tells CD he is recovering from the illness with which he was afflicted when CD visited.

News of family and friends, much of it about forthcoming marriages: Fanny Owen and R. M. Biddulph, Fanny Mackintosh and Hensleigh Wedgwood. Charlotte Wedgwood will write to him of her own engagement to Charles Langton.

He is staying on the Isle of Wight because he has been unwell. He is thought to be in danger of contracting consumption, and the climate is beneficial. He is convalescent now, but will spend the winter there.

Offers to forward any natural history stores CD may want.

Writes of the pleasure all feel in CD's continued good health and joy in his voyage.

Tells of the banana tree he bought, which he sits under and thinks of CD "in similar shade".

CD's financial accounts are correct.